Research has found no one underlying cause of Fibromyalgia. Research is ongoing, but there is agreement that Fibromyalgia patients have an enhanced pain sensitivity and response originating from the central nervous system. Traumatic illness or injury may trigger the disease. Additional research is continuing to determine other factors that may lead to the development of Fibromyalgia including: genetics, environment, autoimmune dysfunction, nutritional deficiencies and connective tissue disease.